For more than 25 years, clinicians around the world have relied on UpToDate as their primary resource for medical knowledge at the point of care. The knowledge contained in UpToDate is evidence-based and continuously updated, but it is not merely an aggregation and report of the latest research; UpToDate presents a comprehensive synthesis of the evidence, followed by recommendations that can be acted on at the point of care. It combines an advanced publishing platform with the rigor of a sophisticated editorial process managed by a faculty of accomplished physician authors and editors, renowned leaders in their specialties.